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The Science Behind Calm Clarity

Clinically studied ingredients. Precisely dosed. Built for cognitive stability, not stimulation.

The Entourage Effect

Some ingredients work on their own. But when the right compounds are combined in the right ratios, their effects multiply.

Wyse is formulated so each ingredient enhances the others:

  • Ketones fuel cellular energy
  • Citicoline sharpens neural signaling
  • Paraxanthine stabilizes alertness
  • Ergothioneine protects neurons under stress
  • Zembrin smooths mood and stress response


Alone, each performs. Together, they calibrate.

Why It Works

5 Clinically Dosed Ingredients

No stimulants. No sugar crashes. Just steady cognitive fuel.

goBHB ® (Beta-Hydroxybutyrate Ketones)

What it is
goBHB® is a bio-identical form of beta-hydroxybutyrate — the primary ketone your body naturally produces during ketosis. It serves as an alternative fuel source for the brain.

What it does
Unlike glucose, ketones provide clean, efficient cellular energy without triggering insulin spikes. goBHB® crosses the blood-brain barrier quickly, supplying mitochondria with usable fuel in minutes.

Clinically shown to:

  • Elevate blood ketone levels 0.5–1.5 mM for hours
  • Support sustained mental endurance and metabolic stability
  • Provide alternative brain fuel during cognitive demand

Entourage Role
goBHB® forms the energetic foundation of the formula. It fuels the brain at the cellular level so the other ingredients can enhance signaling, focus, and stress resilience more effectively.

Clinical Studies

Cognizin ® (Citicoline)

What it is
Cognizin® is a clinically researched form of citicoline that supports brain membrane health and acetylcholine production — a neurotransmitter essential for focus and working memory.

What it does
It enhances neural signaling efficiency, supporting sharper attention, reaction speed, and mental clarity under pressure.

Clinically shown to:

  • Improve vigilance and sustained attention
  • Support working memory performance
  • Increase phosphodiesters linked to neural membrane integrity

Entourage Role
Cognizin® upgrades the “wiring.” While ketones fuel the brain, citicoline improves how efficiently signals move through it.

Clinical Studies


enfinity ® (Paraxanthine)

What it is
enfinity® is paraxanthine — the primary metabolite your body produces after consuming caffeine. It delivers alertness without the typical stimulant crash or anxious spike.

What it does
Unlike caffeine, paraxanthine does not overstimulate the nervous system. It promotes steady alertness while avoiding sharp dopamine surges and abrupt crashes.

Clinically shown to:

  • Improve sustained attention and short-term memory
  • Support clean alertness with lower perceived anxiety
  • Increase energy expenditure without elevating heart rate in the same way as caffeine

Entourage Role
Paraxanthine stabilizes alertness. It complements ketones by maintaining cognitive drive without overstimulation.

Clinical Studies

MitoPrime® (L-Ergothioneine)

What it is
MitoPrime® is a highly bioavailable form of L-ergothioneine — a unique antioxidant that accumulates in mitochondria, the energy centers of cells.

What it does
It helps defend neurons from oxidative stress generated during intense cognitive work, supporting long-term cellular resilience.


Clinically shown to:

  • Elevate circulating ergothioneine levels
  • Reduce oxidative stress markers
  • Support memory in adults with cognitive decline

Entourage Role
MitoPrime® protects the system. While other ingredients push performance, ergothioneine defends brain cells from wear and stress.

Clinical Studies

Zembrin® (Sceletium tortuosum Extract)

What it is
Zembrin® is a standardized extract of Sceletium tortuosum, clinically studied for mood balance and stress regulation.

What it does
It supports serotonin pathways and modulates stress response signaling, helping reduce emotional volatility and cognitive “noise.”

Clinically shown to:

  • Reduce amygdala hyperactivity (fMRI studies)
  • Support executive function and cognitive flexibility
  • Promote calm focus without sedation

Entourage Role
Zembrin® smooths the ride. It balances mood and stress pathways so clarity feels calm, not frantic.

Clinical Studies

Full Ingredient List & Formula FAQs

Everything inside Wyse is here. No proprietary mystery blends. No hidden stimulants.

Wyse is formulated around what we call The Entourage Effect.


Each ingredient targets a different part of cognitive performance:

  • goBHB® fuels brain cells at the mitochondrial level
  • Cognizin® enhances neural signaling and acetylcholine production
  • enfinity® (paraxanthine) stabilizes alertness without caffeine spikes
  • MitoPrime® protects neurons from oxidative stress
  • Zembrin® balances mood and stress-response pathways

Individually, they perform. Together, they calibrate focus, energy, and emotional stability without overstimulation.

No.

Wyse contains zero caffeine.

Instead, it uses paraxanthine (enfinity®), the primary metabolite your body naturally produces from caffeine. It supports alertness without the spike-crash cycle or anxious overstimulation.

Sugar spikes blood glucose and insulin, which often leads to energy crashes.

goBHB® ketones provide an alternative fuel source for the brain that supports steady cellular energy without triggering sugar fluctuations. This is foundational to Wyse’s stable, non-rollercoaster experience.

Yes.

Each of the five core ingredients in Wyse has human clinical research supporting its role in cognitive performance, attention, stress modulation, or cellular resilience.

We link directly to published studies so you can review the data yourself.

Wyse uses small amounts of non-sugar sweeteners to maintain flavor without adding sugar or impacting blood glucose levels.

The goal is metabolic stability — no sugar spikes, no insulin crashes.

The core ingredients in Wyse are generally recognized as safe and studied for daily use within clinically researched ranges.

As always, if you are pregnant, nursing, or have a medical condition, consult your healthcare provider before use.

Two Formats. One Formula.

Same active doses. Same results. Just a different format.

Wyse Founders Blend - 12oz Cans

Wyse Founders Blend
12oz Cans

Steady clarity you can sip.
  • 12oz lightly carbonated
  • Available in 6–48 packs
  • Built for consistent daily use
Starting at
$32.40
Wyse No. 1 - 4oz Shot

Wyse No. 1 - 4oz Shot

Fast Clarity. Zero Bulk.
  • 4oz non-carbonated
  • Bold flavor, less liquid — same full dose in every serving
  • Ideal for travel or on-the-go
Starting at
$27.00

Disclaimer: The studies referenced above examine individual ingredients and their mechanisms of action. The Wyse formulation has not been evaluated as a whole in a clinical trial.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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